Metabolites ea THC e matla ho feta THC

Bafuputsi ba fumane hore metabolite ea mantlha ea THC e lula e le matla ho ipapisitse le data e tsoang ho mefuta ea litoeba. Lintlha tse ncha tsa lipatlisiso li fana ka maikutlo a hore metabolite ea mantlha ea THC e lutseng ka har'a moroto le mali e kanna ea sebetsa ebile e sebetsa joalo ka THC, haeba ho se joalo. Tlhaloso ena e ncha e hlahisa lipotso tse ngata ho feta kamoo e li arabang kateng. Ho latela phuputso ea morao-rao e phatlalalitsoeng ho Journal of Pharmacology and Experimental Therapeutics, psychoactive metabolite ea THC, 11-hydroxy-THC (11-OH-THC), e na le matla a kelello a lekanang kapa a maholo ho feta THC (Delta-9 THC).

Thuto, e nang le sehlooho se reng "The Intoxication Equivalence of 11-Hydroxy-Delta-9-THC (11-OH-THC) Relative to Delta-9-THC," e bontša kamoo metabolites ea THC e bolokang ts'ebetso kateng. Hoa tsebahala hore THC e senya mme e hlahisa metsoako e mecha e khahlang ha e decarboxylate mme e sebetsa 'meleng oa motho. "Phuputsong ena, re entse qeto ea hore metabolite ea mantlha ea THC, 11-OH-THC, e bonts'a ts'ebetso e lekanang kapa e kholo ho feta THC ka panya cannabinoid mohlala oa ts'ebetso ha e tsamaisoa ka kotloloho, esita le ho nahana ka liphapang tsa litsela tsa tsamaiso, thobalano, pharmacokinetics le pharmacodynamics," thuto e re. "Lintlha tsena li fana ka leseli la bohlokoa mabapi le ts'ebetso ea bioloji ea metabolites ea THC, e tsebisa lipatlisiso tsa nakong e tlang tsa cannabinoid, le mohlala oa hore na tšebeliso ea THC le metabolism e ama ts'ebeliso ea batho ba cannabis."

Phuputso ena e entsoe ke sehlopha se tsoang Saskatchewan, Canada, ho akarelletsa Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, le Robert B. Laprairie. Tekong, bafuputsi ba kentse likhoto tsa banna ka 11-hydroxy-THC mme ba bona le ho ithuta litlamorao tsa metabolite ena ea THC ha e bapisoa le motsoako oa eona oa motsoali, Delta-9 THC.

Bafuputsi ba ile ba tsoela pele ho re: "Lintlha tsena li bontša hore tekong ea mohatla bakeng sa maikutlo a bohloko, mosebetsi oa 11-OH-THC ke 153% ea THC, 'me tekong ea catalepsy, mosebetsi oa 11-OH-THC ke 78% ea THC. THC. ”

Kahoo, boithuto bo fana ka maikutlo a hore THC metabolite 11-OH-THC e ka bapala karolo ea bohlokoa ts'ebetsong ea tlhaho ea cannabis. Ho utloisisa tšebetso ea eona ha e tsamaisoa ka kotloloho ho tla thusa ho hlalosa lithuto tsa nakong e tlang tsa liphoofolo le batho. Tlaleho e bolela hore 11-OH-THC ke e 'ngoe ea li-metabolite tse peli tsa mantlha tse entsoeng ka mor'a tšebeliso ea cannabis, e' ngoe e le 11-nor-9-carboxy-THC, e sa sebetseng kelellong empa e ka lula maling kapa morotong nako e telele.

Ho latela Litsi tsa US bakeng sa Taolo le Thibelo ea Mafu (CDC), ho tloha lilemong tsa bo-1980, liteko tsa moroto li ne li shebane haholo le 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite ea Delta-9-THC, e leng eona motsoako o ka sehloohong o sebetsang ho cannabis.

Tlaleho e bontša hore leha ho tsuba cannabis hangata ho hlahisa litlamorao ka potlako ho feta ho jeoa ha cannabis, palo ea 11-OH-THC e hlahisoang ka ho kenella e kholo ho feta ea lipalesa tsa cannabis. Tlaleho e fana ka maikutlo a hore lena ke le leng la mabaka a etsang hore lijo tse kentsoeng ka cannabis li fetohe kelello le ho baka pherekano ho ba sa itokisetsang.

THC Metabolites le Teko ea Lithethefatsi

Bopaki bo bontša hore cannabis e ama basebelisi ka tsela e fapaneng ho latela tsela ea tsamaiso. Phuputso ea 2021 e phatlalalitsoeng ho Permanent Journal e bontšitse hore litlamorao tsa ho ja li-cannabis li kholo ho feta tsa ho tsuba cannabis ka lebaka la metabolism ea 11-OH-THC.

"The bioavailability ea THC ka vaporization ke 10% ho 35%," bafuputsi ba ngotse. "Ka mor'a ho kenngoa, THC e kena ka har'a sebete, moo boholo ba eona bo tlosoang kapa bo kenngoa ka har'a 11-OH-THC kapa 11-COOH-THC, 'me THC e setseng le metabolites ea eona e kena maling. Ka tloaelo, halofo ea bophelo ba plasma ea THC ho basebelisi ka linako tse ling ke matsatsi a 1 ho isa ho a 3, athe ho basebelisi ba sa foleng, e ka nka matsatsi a 5 ho isa ho a 13.

Boithuto bo bonts'a hore nako e telele kamora hore litlamorao tsa psychoactive tsa cannabis li felile, metabolites ea THC joalo ka 11-OH-THC e ka lula maling le morotong nako e telele. Sena se hlahisa liphephetso bakeng sa mekhoa e tloaelehileng ea ho lekola hore na bakhanni le baatlelete ba na le bothata ka lebaka la ts'ebeliso ea cannabis. Mohlala, bafuputsi ba Australia ba ntse ba leka ho fumana hore na ke nako efe eo cannabis e ka sitisang ts'ebetso ea ho khanna. Ketsahalong e 'ngoe, Thomas R. Arkell, Danielle McCartney, le Iain S. McGregor ba tsoang Lambert Initiative Univesithing ea Sydney ba ile ba ithuta phello ea cannabis ho bokhoni ba ho khanna. Sehlopha se ile sa etsa qeto ea hore cannabis e sitisa bokhoni ba ho khanna lihora tse 'maloa ka mor'a ho tsuba, empa ho senyeha hona ho fela pele THC metabolites e tlosoa maling, ka metabolites e phehella' meleng libeke kapa likhoeli.

"Bakuli ba sebelisang lihlahisoa tse nang le THC ba lokela ho qoba ho khanna le mesebetsi e meng e sa sireletsehang (mohlala, ho sebetsa mechine), haholo-holo nakong ea phekolo ea pele le lihora tse 'maloa ka mor'a tekanyo e' ngoe le e 'ngoe," bangoli ba ngotse. "Le haeba bakuli ba sa ikutloe ba holofetse, ba ntse ba ka fumana hore ba na le tšoaetso ea THC. Ho feta moo, bakuli ba cannabis hajoale ha ba lokolohe litekong tsa lithethefatsi tse tsamaeang le tsela le likotlo tse amanang le tsona tsa molao."

Patlisiso ena e ncha e mabapi le 11-OH-THC e bonts'a hore lithuto tse ling lia hlokahala ho utloisisa ka botebo hore na metabolite ea THC e ama 'mele oa motho joang. Ke ka boiteko bo tsoelang pele feela re ka senolang ka botlalo liphiri tsa metsoako ena e ikhethang.